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Minggu, 07 Januari 2018

Frontiers | What's New in the Toolbox for Constipation and Fecal ...
src: www.frontiersin.org

In fecal incontinence (FI), surgery may be carried out if conservative measures alone are not sufficient to control symptoms. There are many surgical options described for FI, and they can be considered in 4 general groups.

  • Restoration and improvement of residual sphincter function
  • sphincteroplasty (sphincter repair)
  • Correction of anorectal deformities that may be contributing to FI
  • Sacral nerve stimulation
  • Replacement / imitation of the sphincter or its function
  • Narrowing of anal canal to increase the outlet resistance without any dynamic component
  • Anal encirclement (Thiersch procedure)
  • Radiofrequency ablation ("Secca procedure")
  • Nondynamic graciloplasty ("bio-Thiersch")
  • Implantation/injection of microballoons, carbon-coated beads, autologous fat, silicone, collagen.
  • Dynamic sphincter replacement
  • Implantation of artificial bowel sphincter (neosphincter)
  • Dynamic graciloplasty
  • Antegrade continence enema (ACE)/ antegrade colonic irrigation
  • Fecal diversion (stoma creation)

The relative effectiveness of surgical options for treating fecal incontinence is not known. A combination of different surgical and non-surgical therapies may be optimal.

A surgical treatment algorithm has been proposed for FI, although this did not appear to include some surgical options. Isolated sphincter defects may be initially treated with sphincteroplasty and if this fails, the patient can be assessed for sacral nerve stimulation. Functional deficits of the external anal sphincter (EAS) and/or internal anal sphincter (IAS), i.e. where there is no structural defect, or only limited EAS structural defect, or with neurogenic incontinence, may be assessed for sacral nerve stimulation. If this fails, neosphincter with either dynamic graciloplasty or artificial anal sphincter may be indicated. Substantial muscular and/or neural defects may be treated with neosphincter initially.


Video Surgical management of fecal incontinence



Sphincteroplasty (sphincter repair)

This operation aims to repair sphincter defects (which may be of unknown cause) or damage from trauma (usually caused by obstetric damage). Where the sphincter has separated from a tear, this procedure brings these ends back together. Primary sphincteroplasty is repair carried out soon after the trauma has occurred, whilst other repairs may be carried out years after the original trauma (secondary or delayed sphincter repair), usually because the trauma went unrecognised. Usually, sphincter defects are in the anterior position on the sphincter, when an anterior sphincteroplasty may be carried out. Where the sphincter defect is laterally or posteriorly placed, this carries a less successful outcome. Overlapping anterior sphincteroplasty is preceded by a bowel preparation and possibly antibiotics. Once the patient is under anesthesia, an incision is made in front of the anus (the anterior perineum). Scar tissue is removed and the mucosa of the anal canal separated from the damaged sphincter. The sphincter is cut and its ends overlapped and then stitched back together. The exact method of the procedure varies, e.g. the cut sphincter may be stitched back end to end, rather than overlapped, or the IAS and EAS may be repaired as separate stages. Sphincter repair may sometimes be combined with an anterior levatorplasty (an operation to tighten the pelvic floor). A surgical drain is left to prevent buildup of fluid. After the operation, sitz baths are recommended to maintain hygiene during healing, and laxatives prescribed to avoid hard stool. Overlapping anterior sphincteroplasty improves FI symptoms in the short term in most (50-80%) patients with sphincter defects. Thereafter, continence deteriorates. Most who undergo this operation are incontinence again after 5 years. Poor results with this procedure may be related to pelvic floor denervation (nerve damage). Primary sphincter repair is inadequate in most women with obstetric ruptures following vaginal delivery. Residual sphincter defects remain in most and around 50% remain incontinent. Residual sphincter defect following the operation (as demonstrated by endoanal ultrasonography) then the procedure may be repeated.


Maps Surgical management of fecal incontinence



Postanal repair

This procedure aims to improve FI by restoring the anorectal angle and lengthen the anal canal. The main indication is denervation of the pelvic floor (e.g. descending perineum syndrome). After the patient is anesthetized, an incision is made posterior to (behind) the anus and a space between the EAS and IAS is opened up. This plane is followed, freeing the rectum from its attachment to the pelvic floor. Puborectalis and pubococcygeus are folded and held with stitches. These folds will lengthen the anal canal. It is safe and simple, but long term improvements in FI are poor (30-40%). Total pelvic floor repair refers to a procedure combining postanal and anterior anal repair.


Hirschsprung disease surgery | Children's Hospital Colorado
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Perianal injectable bulking agents

These procedures aim to inject bio-compatible material into the walls of the anal canal, aiming to bulk out these tissues. This may bring the walls of the anal canal into tighter contact, raising the resting pressure, creating more of a barrier to the loss of stool, and reducing FI. Originally, this technique was described for urinary incontinence, but has since been used for FI, especially passive soiling due to IAS dysfunction. This measure has many advantages over more invasive surgery, since there are rarely any serious complications and the procedure can be carried out under local anesthetic on an out patient basis. Many different materials have been used as perianal injectable bulking agents, including: autologous fat (fat tissue transferred from elsewhere in the body), Teflon, bovine glutaraldehyde cross-linked collagen (collagen from cows), carbon-coated zirconium beads, polydimethylsiloxane elastomer, dextranomer/non-animal stabilised hyaluronic acid, hydrogel cross-linked with polyacrylamide, porcine dermal collagen (collagen from pig skin), and synthetic calcium hydroxylapatite ceramic microspheres. Dextranomer in stabilised hyaluronic acid improves continence for a little over half of patients in the short term. However, future trials are required. Dextranomer is marketed as Solesta, bio-compatible Silicone is also referred to as a PTQ implant and carbon coated beads as Durasphere. The bulking material can be introduced as either intersphincteric (into the space between the IAS and the EAS) or submucosal (under the mucosal layer) injections.Ultrasonound guidance may be used during the injections, which may be more effective than the surgeon simply palpating (feeling) where to inject. A Cochrane systematic review of the efficacy of this type of treatment for FI reported that PTQ implants were the most widely used material, but that there was currently insufficient evidence to be considered to assess the effectiveness of injectable bulking agents. A randomized trial by Dehli et al. compared perianal injectable bulking agents to sphincter training and biofeedback, and found the former to be superior. Both methods lead to an improvement of FI, but comparisons of St Mark's scores between the groups showed no difference between treatments.


Frontiers | What's New in the Toolbox for Constipation and Fecal ...
src: www.frontiersin.org


Sacral nerve stimulation

Sacral nerve stimulation was originally used in urinary incontinence. It was first used to treat FI in 1995. The procedure involves implantation of an electrical device (an implanted pulse generator, IPG) which applies a low amplitude electric current to a sacral nerve (usually S3). This appears to modulate the nerves and muscles of the pelvic floor and rectum. A Cochrane review of the efficacy of sacral nerve stimulation concluded that more research was needed, but can be helpful in selected people with FI, and reduce symptoms in selected people with constipation. It is possible to simulate the effect of SNS without surgery. This is trial usually lasts around 2-3 weeks, where a temporary percutaneous peripheral nerve electrode is placed in the lower back, and then connected to an external stimulator. This trial may not always accurately predict a successful outcome. If there is an improvement, a permanent electrode can be implanted on the sacrum and connected to an stimulator which is in turn implanted in the lower abdominal wall or in the buttock. Implanted stimulators usually last 8 years. The patients who may benefit from SNS include those with intact anal sphincters and those with a history of unsuccessful anal repair. Complications of the surgery are rare, including pain and infection, which may require implant removal in 5% of cases. The effects of SNS may include increased resting and squeeze anal tone, and improved rectal sensitivity. There is reported reduction of involuntary loss of bowel contents and increased ability to postpone defecation. A substantial percentage of patients regain full continence. Patient quality of life has also been shown to be improved after the procedure.


Management of Benign Ano-rectal disorders: ACG Clinical Guideline ...
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Dynamic graciloplasty

In the 1950s described an operation using the gracilis muscle from the inner thigh and wrapping it around the anus to function as a new anal sphincter (neosphincter). Non dynamic graciloplasty was not particularly successful because the gracilis is mostly composed of type II, fast-twitch, fatiguable muscle fibres, whereas the sphincter ideally needs to be able to automatically contract for long periods. A neurostimulation device with an impulse generator can be implanted to adapt the muscle to prolonged contraction (dynamic graciloplasty). Over time, the muscle becomes mostly composed of type I, slow twitch, fatigue resistant fibres. The patient uses an external magnetic programming device to deactivate the electrical stimulation, relaxing the muscular contraction and enabling defecation at a voluntary time. Dynamic graciloplasty may be indicated for patients with a completely destroyed anal sphincter or a torn sphincter with a large gap between both ends that is not amenable to repair. The procedure involves detachment of the gracilis from the leg, preserving both its blood supply and innervation. The muscle is then moved to wrap around the anal canal completely, and also attached to the periosteum of the inferior ramus of the pubic bone. Various arrangements are described, depending upon the length of the gracilis. The implanted stimulator electrode is placed intramuscularly (within the muscle), very close to the gracilis nerve, and the impulse generator is placed subcutaneously (under the skin). The success rate of the operation is between 40-60%, and varies with surgeon experience. The complication rate is high, (infections 28%, device problems 15%, and leg pain 13%) but these are usually treatable without influence on the final result. A second operation may be required for some complications. When dynamic graciloplasty is successful in curing FI, up to 50% of patients may develop signs and symptoms of obstructed defecation.


Urinary incontinence - Wikipedia
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Artificial bowel sphincter (artificial anal sphincter)

This is also termed artificial anal sphincter or neosphincter. The usual surgical approach is through the perineum or alternatively via the vagina. The artificial bowel sphincter involves the implantation of 3 components: (i) A fluid filled silicone elastomer cuff placed around the anus, (ii) a liquid filled, pressure-regulating balloon positioned in the peritoneal fat, and (iii) a manual pump connecting these components (placed in either the labia majora or the scrotum). When the cuff is inflated, the anal canal sealed. The fluid is transferred to the balloon by the manual pump, resulting in deflation of the cuff, opening of the anal canal and allowing for defecation. This procedure improves FI scores and quality of life, and continence is excellent when the procedure works (successful outcome in 85% patients with a functioning device). The procedure is less technically demanding than the graciloplasty, but there is the disadvantage of using foreign material, which can erode through the anal canal. As with graciloplasty, obstructed defecation may develop with a working device, and may be treated with enemas. Complications include infection, which may warrant temporary removal of the device. Graciloplasty and artificial anal sphincter both significantly improve continence, with artificial anal sphincter being superior, however both methods have high rates of complications.


Presnted by Shiva Golian, D.O. - ppt video online download
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Anal encirclement (Thiersch procedure)

This was originally described as a surgical management for rectal prolapse. This operation essentially involves encircling the anal canal with implanted foreign material. Various materials have been used, including nylon, silk, fascia strips, silver wire, and silastic bands. Anal encirclement effectively supplements the anal sphincter, narrowing the anal canal and its barrier function to stool, without altering voluntary control. Since complications are common, and can be serious (fecal impaction, infection, erosion of encirclement through anal canal), modern surgeons prefer to perform colostomy.


Presnted by Shiva Golian, D.O. - ppt video online download
src: slideplayer.com


Radiofrequency ablation ("Secca procedure")

This refers to temperature-controlled radiofrequency energy being delivered to the anal canal, and is marketed as the SECCA procedure. This procedure aims to create a controlled scarring and stricturing of the anal canal. In theory, it is thought that radiofrequency induced IAS injury may cause collagen deposition and fibrosis (scarring), resulting in the affected area tightening. Specialized surgical instrument called a radiofrequency handpiece is used. It has 4 needles which enter the IAS and heat up to 85 °C. This causes the water molecules in the tissue to vibrate with subsequent frictional heating. The hand piece is cooled by water and monitors the temperature of the tissues it is applied to for safety. It is thought that the improvement in FI occurs over time as collagen is deposited and the tissues undergo remodeling. The procedure is carried out under local anesthesia (with or without conscious sedation) on an outpatient basis. There appear to be relatively few serious complications. Initial studies of the SECCA procedure have shown promising improvements in quality of life and FI severity scores, however large randomized control trials and systematic reviews are currently lacking.


New Surgical Options for Fecal Incontinence: Dr. Vo of Northwest ...
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Antegrade continence enema

This procedure involves the surgical creation of a stoma (either an appendicostomy, cecostomy, or sigmoidostomy), which thereafter functions as an irrigation port. This antegrade colonic irrigation aims to introduce fluid to wash out the colon at regular intervals. The idea is to ensure regular emptying of the colon and rectum and hopefully, prevent involuntary loss of bowel content. The Malone antegrade continence enema (MACE) is where an appendicostomy is created, i.e. the vermiform appendix is stitched to the abdominal wall to form a stoma. ACE is often necessary in addition to others when FI is complicated by neuropathy and/or an incomplete IAS. Patients may have persistent leakage of fluid per rectum for several hours following the irrigation.


Mayo Clinic First to Implant Device to Solve Fecal Incontinence ...
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Fecal diversion (stoma creation)

Diversion may be a temporary measure in the management of FI, e.g. to allow healing of another surgical procedure, or it may be a definitive procedure. Stoma creation is considered to be the last resort treatment, when all other attempts to improve symptoms have been unsuccessful, although they are associated with many problems such as odor associated with leakage of stool and flatus from the stoma. The stoma may be colostomy (where the colon is ended in a stoma) or ileostomy (where the ileum is ended in a stoma). Both may involve the creation of an internal waste-holding reservoir in a procedure developed by Dr. Nils Kock in the late 1960s.

Diversion colitis is inflammation of the section of gut through which stool no longer passes. This condition arises because normally the lining of the gut obtains some of its nutrients from the fecal stream. This condition may cause a foul smelling, mucous rectal discharge from the distal, unused colon.


Validation of Risk Factors for Fecal Incontinence in Patient ...
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References


GASTROENTEROLOGY Suggestions for Lecturer -1-hour lecture - ppt ...
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External links

  • NICE guidance IPG159: Stimulated graciloplasty for faecal incontinence
  • NICE guidance IPG099: Sacral nerve stimulation for faecal incontinence

Source of the article : Wikipedia

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